Success in discovery of innovative chemical solutions from Natural Products depends heavily on the underlying Natural Product collections, i.e. the “libraries”. While many just randomly select natural sources, IMD Natural Solutions‘ compounds and sources match nature´s chemical diversity. Our leading collection of fungal and bacterial genetic sources, comprising ca. 40.000 microbial strains and ca. 6.000 plant and other biological raw materials (up to the multi-kg scale) we, selected by chemotaxonomy in order to minimize diversity.
Moreover, we established out of the source collection the world largest commercially accessible library of pure Natural Product compounds (ca. 15.000 compounds) and created a special “Focus on Edibility” sub-library for rapid (consumer good) product generation.
To have a large Natural Product collection is fine and key. However, it is equally important to transfer the collection into a screenable format. Therefore we have processed our entire collection as a “ready-to-screen” large screening file of Natural Product sources and compounds for rapid lead and product discovery. To cater to the specific needs of the food industry we have additionally created our edible screening file, focusing on culinary fruit, spices, vegetables, herbal teas, and edible mushrooms and carefully selected on a global scale for edible track record and history.
The screening files comprise a total of 100.000 Natural Product samples in an operation-ready miniaturized and microtiter plated format. The samples include ca. >14.000 pure Natural Product samples (NatPure) and ca. 87.000 extract Natural Product samples following the source origin breakdown as depicted beside.
The extract Natural Product samples include the Advanced Extract and the Pre-Fractionated Extract formats originally developed at Bayer HealthCare for maximum compatibility with modern HTS-based cellular and biochemical assay formats allowing for the utmost avoidance of false positive signals due to highly polar and/or lipophilic compounds and for rapid hit deconvolution and dereplication.
Our screening files are accessible for lead discovery in the field of pharma, animal health, and crop protection only through our exclusive service partner Charles River as part of the Charles Rivers´ fully integrated discovery services. Thereby a seamless integration of our Natural Product expertise and experience into an overarching drug discovery program is warranted without any need for the client to be bothered with any type of backstage engineering.
IMD Natural Solutions operates a unique Natural Products informatics platform combining public and proprietary databases to a sophisticated Natural Product profile delivery system: At the same moment in time and just a “mouse click away” biological activity profiles and chemical information can be retrieved delivering a combined profile for an individual compound or product candidate.
The basis for our profiles is chemical structural information. We operate one of the world’s largest and most powerful dereplication databases, allowing for rapid (re-) identification of already known compounds. Combined with full sub-structure searchable public and proprietary structure-activity databases, toxicology prediction databases and our proprietary therapeutic area focused NP Silico databases we can rapidly guide discovery programs towards innovation and novelty without losing valuable input to such programs from previous findings and without spending unnecessary resources to the “re-invention of the wheel”.
Finally our unparalleled Bioprofiling database allows the rapid discovery and/or the fast bioactivity profiling of new and existing product solutions through the combination of bioactive compounds, natural sources and potential application areas. This element of our Natural Product informatics platform is unique in the industry and boasts with more than 12 million data entries on biological activity of Natural Products.
We operate a full-fledged laboratory infrastructure covering all capabilities and instrumentation required to deliver Natural Product-derived solutions in any scale.
In addition to our in-house capabilities, we have longstanding, well-rehearsed partnerships for ton scale supply and semi-synthetic solutions, combining our Natural Product expertise, our purification and analytical capabilities with external sourcing, fermentation and contract manufacturing: